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Painkillers with the active ingredient acetaminophen such as Johnson & Johnson (JNJ)’s Tylenol have been linked to serious skin reactions including rash and blisters, U.S. regulators said.

Reports to the Food and Drug Administration’s adverse event database reveal the most serious reactions, while rare, led to hospitalizations and deaths. The majority of cases involved single-ingredient acetaminophen products, the FDA said yesterday in a statement. The agency advised people who develop a skin rash or reaction to stop taking the drug and seek medical attention. 

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