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How long is too long to be on antidepressants?

More Americans are taking antidepressant medications like Prozac and Zoloft for extended periods of time: One-quarter of people on the drugs have used them for a decade or more, according to data from the National Center for Health Statistics. But even the longest rigorous studies of antidepressants’ safety and efficacy have followed patients for only a couple of years.

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